Nanowired delivery of mesenchymal stem cell reduces diabetes induced aggravation brain damage following heatstroke

by Sharma, Hari Shanker; Feng, Lianyuan; Lafuente, Jose Vicente; Muresanu, Dafin F.; Tian, Z. Ryan; Patnaik, Ranjana; Sharma, Aruna

Our military personnel are often exposed to combat operations in hot environments in summer months (40 to 42C) that often lead to heatstroke. Since endocrine disorders e.g., diabetes could result from posttraumatic stress disorders (PTSD) in military populations; these soldiers are highly vulnerable to additional heat stress. Previous reports from our lab suggest that diabetic rats showed greater brain pathology after heat stress. This suggests that military personnel with diabetes in heat stress have higher brain pathology during combat stress or other activities. Since stem cells are known to induce neuroprotection we examined whether nanodelivery of mesenchymal stem cells (MSCs) could enhance the potential neuroprotective effects of stem cells and reduce the aggravation of brain pathology in heat stress in diabetic rat model. Our observations clearly show that nanodelivery of MSCs markedly attenuated heat stress induced brain pathology in diabetic rats.

NSTI Nanotech 2014, NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014