Straightforward and Expeditious One-Pot Tandem Synthesis of 3,5-Diaryl-1,2,4-Selenadiazoles from Aryl Nitriles

by Majnooni, Sahar; Almansaf, Zainab; Tsuji, Miu; Khosropoura, Ahmad R.; Zali-Boeini, Hassan; Beyzavi, M. Hassan

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A one-pot process for the efficient synthesis of 3,5-diaryl-1,2,4-selenadiazoles from aryl nitriles has been developed. This tandem transformation was performed in excellent yields (91-98%) via in situ selenoamidation and a subsequent oxidative dimerization reaction. This method features relatively mild reaction conditions, operational simplicity, straightforward separation of the products, and the utilization of inexpensive reagents.

Journal
Synthesis (Stuttgart)
Volume
51
Issue
22
Year
2019
Start Page
4279
ISBN/ISSN
0039-7881
DOI
10.1055/s-0039-1690126