Synthesis of bridged medium-sized rings through the intramolecular Pauson-Khand reaction

by Lovely, C. J.; Seshadri, H.; Wayland, B. R.; Cordes, A. W.

[GRAPHICS] A series of aromatic enynes containing steric buttressing elements were prepared and evaluated in the NMO-mediated Pauson-Khand cyclization. O-Allyl systems led to the expected angularly fused products, whereas the O-butenyl and O-pentenyl derivatives afforded the unprecedented bridge systems.

Journal
Organic Letters
Volume
3
Issue
16
Year
2001
Start Page
2607-2610
URL
https://dx.doi.org/10.1021/ol016308s
ISBN/ISSN
1523-7052; 1523-7060
DOI
10.1021/ol016308s