Enzymichromism - Determination of the Dielectric-Properties of an Enzyme Active-Site
by Kanski, R.; Murray, C. J.
The negative solvatochromic and enzymichromic properties of 4-carbamidopyridinium cyclopentadienylide, 3, are presented. Tle 78 nm bathochromic shift of the long wavelength absorption band of 3 upon going from water to the horse liver alcohol dehydrogenase (HLADH)-NADH ternary complex is consistent with a low dielectric for the hydrophobic binding pocket of this enzyme.
- Journal
- Tetrahedron Letters
- Volume
- 34
- Issue
- 14
- Year
- 1993
- Start Page
- 2263-2266
- URL
- https://dx.doi.org/10.1016/s0040-4039(00)77589-7
- ISBN/ISSN
- 1873-3581; 0040-4039
- DOI
- 10.1016/s0040-4039(00)77589-7