TiO2 Nanowired Cerebrolysin enhances neuroprotective effects of mesenchymal stem cells following concussive head injury at hot environments

by Sharma, Hari Shanker; Muresanu, Dafin F.; Feng, Lianyuan; Lafuente, Jose Vicente; Patnaik, Ranjana; Tian, Z. Ryan; Ozkizilcik, Asya; Mössler, Herbert; Sharma, Aruna

Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is needed. Since stem cell therapy enhances neurorepair in brain or spinal cord injuries, this is quite likely that this may be effective in CHI as well. However, this is still unclear whether CHI occurring at high environmental temperature could adversely affect the outcome with regard to brain pathology or sensory motor disturbances. Since our soldiers are often engaged in combat operations in desert environments under high heat conditions, this is likely that their outcome following CHI require special treatment using combination therapy. In this investigation we used nanowired delivery of mesenchymal stem cells (MSCs) intravenously following CHI and also added a known neuroprotective multimodal drug Cerebrolsyin with or without nanowired delivery to see whether a synergistic better effects of this combination can result in good neurorepair following CHI at high environmental heat situations. Our results showed that a combination of nanowire stem cells and cerebrolysin is the most effective in reducing brain pathology following CHI at hot environment, not reported earlier.

2015 TechConnect World Innovation Conference and Expo and the 2015 Nanotech Conference and Expo, Washington, D.C.