TiO2 nanowired delivery of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) induces profound neuroprotection in concussive head injury

by Sharma, Hari Shanker; Muresanu, Dafin F.; Feng, Lianyuan; Lafuente, Jose Vicente; Patnaik, Ranjana; Tian, Z. Ryan; Ozkizilcik, Asya; Mössler, Herbert; Sharma, Aruna

To develop suitable therapeutic strategies for concussive brain injury (CHI), we have explored the role of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) in a rat model. We delivered this compound alone and also using Titanium nanowires delivery to explore the benefit of nanodrug delivery in CHI. Since CHI induces much more pronounced death and disability and so fat therapeutic approaches are still elusive we showed that this traditional Chinese medicine has some values in CHI. DL-3-n-butylphthalide (DL-NBP) a yellowish oil-like liquid (99.6% purified) is a Traditional Chinese Medicine used for various neurological ailments since ages. The basic mechanisms behind such a neuroprotective effects of DL-NBP are related to its possible strong antioxidative properties. The other causes of CHI include motor vehicle accident or blunt trauma on the head during combat operations. In such CHI cases rehabilitation and supportive strategies costs several millions of USD with only a mild improvement in the victims over time. Thus, we investigated DL-NBP in CHI to reduce brain pathology and behavioral dysfunction using nanotechnologies. Our observations are the first to point out a new role of DL-NBP in treating CHI. Furthermore, the nanowired delivery of NBP is far superior to NBP alone.

2015 TechConnect World Innovation Conference and Expo and the 2015 Nanotech Conference and Expo, Washington, D.C.