Toward the reproducibility of CuIPhEt hydrosilylations

by Spahn, Elizabeth Suzanne; McIntosh, Matt C.; Gawley, Robert E.

The reactivity and enantioselectivity of the chiral C2-sym. N-heterocyclic carbene (NHC) catalyst, CuIPhEt, was optimized toward the hydrosilylation of ketones. Studies on the reaction system have provided access to a scalable procedure with high yields and selectivities on new substrates. The substrate scope has been expanded to test the chemoselectivity of the catalyst system in the presence of other reducible moieties. Extremely high yields and enantioselectivities in the redn. of unfunctionalized alkyl-alkyl ketones have been achieved.