Mn nanoparticles exacerbates closed head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin

by Sharma, Aruna; Feng, Lianyuan; Muresanu, Dafin F.; Lafuente, Jose Vicente; Tian, Z. Ryan; Ozkizilcik, Asya; Smith, Mark A.; Sharma, Hari Shanker

This innovation deals with adverse effects of Mn nanoparticles on brain pathology in concussive head injury. Also Mn nanoparticles treatment alters therapeutic modalities. The novel data presented in the abstract show that Mn exposure to our military personal from various industries, welding or deep mine work could make them more vulnerable to any additional head injury. This work also for the first time showed that neuroprotective agents in Mn treated traumatized group require in high concentration to treat effectively the brain pathologies. These data are strategically very important for further development of industrial or military medicine for health benefits. Furthermore, we have shown that nanowired delivery of 5-HT2 receptor antagonists e.g., ketanserin and ritanserin remarkably attenuated exacerbation of brain pathology after CHI in MN NPs treated group, not reported earlier.

2015 TechConnect World Innovation Conference and Expo and the 2015 Nanotech Conference and Expo, Washington, D.C.