Rapid microwave-assisted syntheses of derivatives of HIV-1 entry inhibitors

by McFarland, Christopher Michael; Vicic, David A.; Debnath, Asim Kumar

The direct amidation of esters with 4-amino-2,2,6,6-tetramethylpiperidine was achieved by computer-controlled microwave irradiation in toluene. The microwave protocol allowed the new amides to be prepared in three hours rather than the three days required by traditional thermal methods.

Journal
Synthesis (Stuttgart)
Issue
5
Year
2006
Start Page
807
ISBN/ISSN
1437-210X; 0039-7881
DOI
10.1055/s-2006-926339