Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage
by Muresanu, Dafin F.; Sharma, Aruna; Patnaik, Ranjana; Nozari, Ala; Mössler, Herbert; Tian, Z. Ryan; Ozkizilcik, Asya; Sharma, Hari Shanker
Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in the Middle East region also exposes them to high environmental heat and silica dust. Thus, it is quite likely that all these combinations of hypertension, silica dust (SiO2 NPs) and carbon NPs following missile explosion or blast injuries in desert high heat lead to exacerbation of brain damage following heat stroke. This hypothesis was tested in our rat model of heat stroke where renal hypertensive rats were intoxicated with SiO2 and single walled carbon nanotubes (SWCNT) before heat exposure. Our innovation showed that TiO2 nanowired cerebrolysin is able to induce profound neuroprotection in chronic hypertensive rats after heat stroke intoxicated with SiO2 NPs and SWCNTs. This indicates a potential role of cerebrolysin in military particularly engaged to combat operation in high desert heat.
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