Nanodrug delivery by single-walled carbon nanotubes (SWCNTs) in the central nervous system induces neurotoxicity. Potential neuroprotective effects of Cerebrolysin

by Sharma, Hari Shanker; Muresanu, Dafin F.; Lafuente, Jose Vicente; Patnaik, Ranjana; Tian, Z. Ryan; Mössler, Herbert; Sharma, Aruna

Our military personnel are often inflicted with brain or spinal cord injury during combat operations caused by gunshot, missile explosions, fall or direct blunt or sharp trauma to their CNS leading to life threatening illnesses. Recently, single-walled carbon nanotubes (SWCNTs) are used for nano drug delivery in cancer therapy however; SWCNTs induced neurotoxicity is not well known. In this innovation, we used Cerebrolsyin, a balanced composition of several neurotrophic factors and active peptide fragments in attenuating SWCNTs induced neurotoxicity in the rat central nervous system (CNS). These observations support the idea that co-administration of Cerebrolsyin with SWCNTs is needed to enhance the neuroprotective effects of nanodrug delivery using SWCNTs as a vehicle.

NSTI Nanotech 2014, NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014