Fe(II)-Catalyzed Amination of Aromatic C-H Bonds via Ring Opening of; 2H-Azirines:Synthesisof213-DisubstitutedIndoles
by Jana, Samaresh; Clements, Mack D.; Sharp, Barry Kyle; Zheng, Nan
A general method for the synthesis of 2,3-disubstituted indoles is; described.Thekeyfeatureofthismethodistheaminationofaromatic; C-HbondsviaFeCl2-catalyzedringopeningof2H-azirines.Themethod; toleratesavarietyoffunctionalgroupssuchasBr,F,NO2,OMe,CF3,; OTBS,alkenes,andOPiv.Themethodcanalsobeextendedtosynthesize; azaindoles.
- Journal
- Organic Letters
- Volume
- 12
- Issue
- 17
- Year
- 2010
- Start Page
- 3736
- ISBN/ISSN
- 1523-7052; 1523-7060
- PMID
- 20681598
- DOI
- 10.1021/ol101130e