Application of Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine to the Asymmetric Synthesis of 2-Aryl and 2-Vinyl Piperidines
by Beng, T. K.; Gawley, R. E.
The highly enantioselective synthesis of 2-aryl- and 2-vinyl-piperidines has been accomplished through a catalytic dynamic resolution (CDR) of N-Boc-2-lithiopiperidine. The method has been applied to the synthesis of both enantiomers of the tobacco alkaloid anabasine.
- Journal
- Organic Letters
- Volume
- 13
- Issue
- 3
- Year
- 2011
- Start Page
- 394-397
- URL
- https://dx.doi.org/10.1021/ol102682r
- ISBN/ISSN
- 1523-7052; 1523-7060
- DOI
- 10.1021/ol102682r