Recombinant Peptide Fusion Protein-Templated Palladium Nanoparticles for Suzuki-Miyaura and Stille Coupling Reactions
by Mosleh, I.; Shahsavari, H. R.; Beitle, R.; Beyzavi, M. H.
This study examined the use of nanoparticles created with recombinant 45-amino acid long peptides fused to green fluorescent protein (GFPuv) to catalyze twelve representative Suzuki-Miyaura and Stille coupling reactions. A method was developed to prepare powders (Pd@GFP) containing protein and synthesized nanoparticles. Next, coupling reactions were performed in a green solvent without nanoparticle purification. Pd@GFP had high turnover frequencies for the synthesis of model compounds including lapatinib (Tykerb (R)) and could be recycled. This study establishes a potentially cost-effective approach to prepare heterogeneous catalysts containing well-defined nanoparticles enabling key C-C bond formation leading to synthetically and pharmaceutically interesting compounds.
- Journal
- ChemCatChem
- Volume
- 12
- Issue
- 11
- Year
- 2020
- Start Page
- 2942-2946
- URL
- https://dx.doi.org/10.1002/cctc.201902099
- ISBN/ISSN
- 1867-3899; 1867-3880
- DOI
- 10.1002/cctc.201902099