Gramicidin channels - A solvable membrane ''protein'' folding problem
by Andersen, O. S.; Saberwal, G.; Greathouse, D. V.; Koeppe, R. E.
The linear gramicidins are peptide antibiotics that form cation-selective channels in lipid bilayers. Gramicidin channels have very well-defined functional characteristics, and the structure of membrane-spanning gramicidin A channels is known at atomic resolution. These features make the gramicidins well suited to study how the amino acid sequence encodes the structure and function of a membrane-spanning channel. We show how one can use electrophysiological measurements to obtain structural information about conducting channels and to quantify the conformational preferences of sequence-substituted gramicidin mutants.
- Journal
- Indian Journal of Biochemistry and Biophysics
- Volume
- 33
- Issue
- 5
- Year
- 1996
- Start Page
- 331-342
- URL
- https://www.webofscience.com/wos/woscc/full-record/WOS:A1996VT47800001
- ISBN/ISSN
- 0975-0959; 0301-1208