Isobenzofuran analogs of sclerophytin A
Isobenzofuran analogs of sclerophytin A are prepared in a highly concise fashion via an aldol-cycloaldol sequence. The analogs exhibit IC 50's as low as 1 micro M in growth inhibitory studies against KB3 cells using an MTT assay. Preferred analogs have one of the following structural formulas, where R is hydrogen or a substituted or unsubstituted lower alkyl group and Ar is a substituted or unsubstituted aryl group.
- Patent Number
- USUS2010331370 A1 2010-12-30
- Application Number
- B2
- Publication Year
- 2013
- URL
- https://scholarworks.uark.edu/pat/38