Zundel-Type H-Bonding in Biomolecular Ions

by Hernandez, O.; Pulay, P.; Maitre, P.; Paizs, B.

Using quantum chemical calculations and infrared multiphoton dissociation (IRMPD) spectroscopy in the fingerprint and X-H stretching regions, we demonstrate here that the all-Ala b (6) fragment ion features a macrocyclic structure with C-2 symmetry. For this structure, the ionizing proton is equally shared by the Ala(1) and Ala(4) amide oxygens in a Zundel-type symmetric (XaEuro broken vertical bar H(+)aEuro broken vertical bar X) H-bond.

Journal
Journal of the American Society for Mass Spectrometry
Volume
25
Issue
9
Year
2014
Start Page
1511-1514
URL
https://dx.doi.org/10.1007/s13361-014-0950-8
ISBN/ISSN
1879-1123; 1044-0305
DOI
10.1007/s13361-014-0950-8