Fusion proteins of collagen-binding domain and parathyroid hormone
by Gensure, Robert C.; Sakon, Joshua; Matsushita, Osamu; Ponnapakkam, Tulasi
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
- Patent Number
- USUS2019135890 A1 2019-05-09
- Application Number
- B2
- Publication Year
- 2019
- URL
- https://scholarworks.uark.edu/pat/360