Rapid microwave-assisted syntheses of derivatives of HIV-1 entry inhibitors

by McFarland, C.; Vicic, D. A.; Debnath, A. K.

The direct amidation of esters with 4-amino-2,2,6,6-tetramethylpiperidine was achieved by computer-controlled microwave irradiation in toluene. The microwave protocol allowed the new amides to be prepared in three hours rather than the three days required by traditional thermal methods.