Photoredox-catalyzed 4+2 annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow.
by Wang, Jiang; Nguyen, Theresa H.; Zheng, Nan
Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions' efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation's efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.
- Journal
- Science China-Chemistry
- Volume
- 59
- Issue
- 2
- Year
- 2016
- Start Page
- 180-183
- URL
- https://dx.doi.org/10.1007/s11426-015-5547-y
- ISBN/ISSN
- 1869-1870; 1674-7291
- DOI
- 10.1007/s11426-015-5547-y