Non-Cd based quantum dots for molecular imaging
by Gao, Jinhao; Chen, Kai; Xie, Renguo; Peng, Xiaogang; Chen, Xiaoyuan
A novel non-Cd based near-IR emitting quantum dots with different surface coating for both passive and active tumor targeting was developed. It is expected that such low toxic, low macrophage uptake quantum dots will be useful for mol. imaging in small animal models and eventually translated into clinic. The mercaptopropionic acid (MPA) coated InAs/InP/ZnSe QDs with emission max. at about 800 nm (QD800-MPA) exhibited high tumor-uptake based upon passive targeting. There are several advantageous properties of QD800-MPA: (i) the emission wavelength of 800 nm ensures the low tissue background and high tissue penetration; (ii) the hydrodynamic diam. of about 10 nm allows renal clearance, minimizes the reticuloendothelial system (RES) uptake, and enhances the possibility of enhanced permeability and retention (EPR) effect; (iii) no cadmium suggests low toxicity to the body; and (iv) the QD800- MPA shows significantly long circulation half-life compared with QD800 ITK carboxyl (QD800-COOH) from Invitrogen.
- Conference
- Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
- Year
- 2010
- Division
- 83-84
- URL
- https://dx.doi.org/10.1115/nemb2010-13018
- ISBN/ISSN
- 9780791843925
- DOI
- 10.1115/nemb2010-13018