Fe(II)-Catalyzed Amination of Aromatic C-H Bonds via Ring Opening of 2H-Azirines: Synthesis of 213-Disubstituted Indoles.
by Jana, Samaresh; Clements, Mack D.; Sharp, Barry K.; Zheng, Nan
A general method for the synthesis of 2,3-disubstituted indoles is described. The key feature of this method is the amination of aromatic C-H bonds via FeCl2-catalyzed ring opening of 2H-azirines. The method tolerates a variety of functional groups such as Br, F, NO2, OMe, CF3, OTBS, alkenes, and OPiv. The method can also be extended to synthesize azaindoles.
- Journal
- Organic Letters
- Volume
- 12
- Issue
- 17
- Year
- 2010
- Start Page
- 3736-3739
- URL
- https://dx.doi.org/10.1021/ol101130e
- ISBN/ISSN
- 1523-7052; 1523-7060
- DOI
- 10.1021/ol101130e