An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease activity

by Xia, Xiaohu; Yang, Miaoxin; Oetjen, L. Kyle; Zhang, Yu; Li, Qingge; Chen, Jingyi; Xia, Younan

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A gold nanocage and dye conjugate has been demonstrated for use with photoacoustic imaging and fluorescence detection of protease activity. The detection sensitivity could be maximized by using gold nanocages with a localized surface plasmon resonance peak away from the emission peak of the dye. These hybrids can be potentially used as multimodal contrast agents for molecular imaging.

Journal
Nanoscale
Volume
3
Issue
3
Year
2011
Start Page
950
ISBN/ISSN
2040-3364
DOI
10.1039/c0nr00874e