An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease activity
by Xia, Xiaohu; Yang, Miaoxin; Oetjen, L. Kyle; Zhang, Yu; Li, Qingge; Chen, Jingyi; Xia, Younan
A gold nanocage and dye conjugate has been demonstrated for use with photoacoustic imaging and fluorescence detection of protease activity. The detection sensitivity could be maximized by using gold nanocages with a localized surface plasmon resonance peak away from the emission peak of the dye. These hybrids can be potentially used as multimodal contrast agents for molecular imaging.
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