Recombinant Peptide Fusion Protein-Templated Palladium Nanoparticles for Suzuki-Miyaura and Stille Coupling Reactions
by Mosleh, Imann; Shahsavari, Hamid R.; Beitle, Robert; Beyzavi, Hudson
This study examined the use of nanoparticles created with recombinant 45-amino acid long peptides fused to green fluorescent protein (GFPuv) to catalyze twelve representative Suzuki-Miyaura and Stille coupling reactions. A method was developed to prepare powders (Pd@GFP) containing protein and synthesized nanoparticles. Next, coupling reactions were performed in a green solvent without nanoparticle purification. Pd@GFP had high turnover frequencies for the synthesis of model compounds including lapatinib (Tykerb (R)) and could be recycled. This study establishes a potentially cost-effective approach to prepare heterogeneous catalysts containing well-defined nanoparticles enabling key C-C bond formation leading to synthetically and pharmaceutically interesting compounds.
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