Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment
by Handa, Masaki; Scheidt, Karl A.; Bossart, Martin; Zheng, Nan; Roush, William R.
[GRAPHICS] A synthesis of the C(1)-C(11) fragment of apoptolidin A has been accomplished by a convergent route involving the stereoselective glycosidation of 9 and the Suzuki cross-coupling reaction of bromodienoate 7 and the vinylborane generated via chemoselective hydroboration of diyne 6 with diisopinocampheylborane.
- Journal
- Journal of Organic Chemistry
- Volume
- 73
- Issue
- 3
- Year
- 2008
- Start Page
- 1031
- ISBN/ISSN
- 0022-3263; 1520-6904
- DOI
- 10.1021/jo702250z