Absolute configuration of 2-(tributylstannyl)pyrrolidine by anomalous dispersion X-ray analysis
by Gawley, Robert E.; Narayan, Sanjay; Vicic, David A.
Enantiopure 2-(tributylstannyl)pyrrolidine hydroiodide may be prepared in excellent yield by TMSI treatment of the corresponding N-Boc compound, which is in turn prepared by asymmetric deprotonation (s-BuLi(.)sparteine) and stannylation, as described in the literature. Crystals of the hydroiodide salt suitable for X-ray analysis were obtained, and although there is some disorder about the butyl groups, analysis using anomalous dispersion establishes the absolute configuration as S.
- Journal of Organic Chemistry
- Start Page
- 0022-3263; 1520-6904