Isobenzofuran analogs of sclerophytin A

by McIntosh, Matthias C.

Isobenzofuran analogs of sclerophytin A are prepared in a highly concise fashion via an aldol-cycloaldol sequence. The analogs exhibit IC 50's as low as 1 micro M in growth inhibitory studies against KB3 cells using an MTT assay. Preferred analogs have one of the following structural formulas, where R is hydrogen or a substituted or unsubstituted lower alkyl group and Ar is a substituted or unsubstituted aryl group.

Patent Number
USUS2010331370 A1 2010-12-30
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