Piezoelectric three-dimensional nanostructures for developing point-of-care biosensors.

by Abraham, Jose K.; Dubaka, Sridhar; Varadan, Vijay K.; Zhou, Huajun; Zhang, Tierui; Tian, Z. Ryan

A review. Minimal invasive determinations of various physiol. parameters are more and more demanding for medical applications. Many techniques have been evolved in nanotechnol. using one dimensional nanostructures to aid the anal. tools for chem. and biosensing, disease diagnosis and treatment. Nanowire sensing probes have potential applications not only in electronics and optoelectronics industry, but have tremendous potential in evaluating minute changes in cellular level, particularly for designing various sensing and diagnosis tools. A review of the development of vertically aligned piezoelectronic nanowire arrays and three-dimensional (3-D) nanostructures for the design of biomedical sensors for point-of- care applications are presented in this paper. The deflections of a vertically aligned piezoelec. nanowire arrays can be used for the generation of voltages and can be used for the measurement of various parameters such as pressure, temperature, blood flow and glucose detection. Vertically aligned ZnO nanostructure has the advantages of generating piezoelec. voltages that can be coupled with MEMS sensors for the development of point-of-care biosensors.

Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring
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