Polyacrylate microgels as antimicrobial agents

by Sharma, Babloo; Clem, Carlie; Striegler, Susanne

Polyacrylate microgels were prepared with altered material composition and explored as antimicrobial agents towards Gram-pos. and -neg. bacteria, such as S. aureus and E. coli. Microbroth dilution assays were used to determine the minimal inhibition concentration and the minimal bactericidal concentration The obtained data are contrasted against vancomycin, which is a commonly used antimicrobial agents on the market. Interestingly, the crosslinking of the material, its polarity, and degree of crosslinking influence the interactions of the material with both types of bacteria. Preliminary insights in the mechanism of the bacterial interaction will be discussed.