Electron-Transfer from Cytochrome B(5) to Cytochrome-C
by Durham, B.; Fairris, J. L.; McLean, M.; Millett, F.; Scott, J. R.; Sligar, S. G.; Willie, A.
The reaction of cytochrome b(5) with cytochrome c has become a very prominent system for investigating fundamental questions regarding interprotein electron transfer. One of the first computer modeling studies of electron transfer and protein/protein interaction was reported using this system. Subsequently, numerous studies focused on the experimental determination of the features which control protein/protein interactions. Kinetic measurements of the intracomplex electron transfer reaction have only appeared in the last 10 years. The current review will provide a summary of the kinetic measurements and a critical assessment of the interpretation of these experiments.