Intermolecular [3+2] Annulation of Cyclopropylanilines with Alkynes, Enynes, and Diynes via Visible Light Photocatalysis
by Nguyen, Theresa H.; Morris, Scott A.; Zheng, Nan
One-step syntheses of carbocycles substituted with amines from simple starting materials remain rare. We recently developed an intermolecular [3+2] annulation of cyclopropylanilines with alkenes and alkynes that enables this one-step synthesis. Herein, we report our findings for a full-scale study of the annulation. Significant expansion of the substrate scope for both cyclopropylanilines and alkynes has been achieved. A range of structurally diverse carbocycles substituted with amines is prepared.
- Journal
- Advanced Synthesis and Catalysis
- Volume
- 356
- Issue
- 13
- Year
- 2014
- Start Page
- 2831-2837
- URL
- https://dx.doi.org/10.1002/adsc.201400742
- ISBN/ISSN
- 1615-4169; 1615-4150
- DOI
- 10.1002/adsc.201400742