Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds

by Majnooni, Sahar; Duffield, Joseph; Price, Jessica; Khosropour, Ahmad Reza; Zali-Boeini, Hassan; Beyzavi, M. Hassan

FindIt!

Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.

Journal
ACS Combinatorial Science
Volume
21
Issue
7
Year
2019
Start Page
516
ISBN/ISSN
2156-8952
DOI
10.1021/acscombsci.9b00045