Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp

by An, Tianying; Kumar, Thallapuranam Krishnaswamy Suresh; Wang, Minglei; Liu, Li; Lay Jr, Jackson Oliver; Liyanage, Rohana; Berry, John P.; Gantar, Miroslav; Marks, Vered; Gawley, Robert E.; Rein, Kathleen S.

The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a periphyton mat from the Florida Everglades.

Journal
Journal of Natural Products
Volume
70
Issue
5
Year
2007
Start Page
730
ISBN/ISSN
1520-6025; 0163-3864
PMID
17432902
DOI
10.1021/np060389p