Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp

by An, T. Y.; Kumar, T. K. S.; Wang, M. L.; Liu, L.; Lay, J. O.; Liyanage, R.; Berry, J.; Gantar, M.; Marks, V.; Gawley, R. E.; Rein, K. S.

The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a periphyton mat from the Florida Everglades.

Journal
Journal of Natural Products
Volume
70
Issue
5
Year
2007
Start Page
730-735
URL
https://dx.doi.org/10.1021/np060389p
ISBN/ISSN
1520-6025; 0163-3864
DOI
10.1021/np060389p