Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp
by An, Tianying; Kumar, Thallapuranam Krishnaswamy Suresh; Wang, Minglei; Liu, Li; Lay Jr, Jackson Oliver; Liyanage, Rohana; Berry, John P.; Gantar, Miroslav; Marks, Vered; Gawley, Robert E.; Rein, Kathleen S.
The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a periphyton mat from the Florida Everglades.
- Journal
- Journal of Natural Products
- Volume
- 70
- Issue
- 5
- Year
- 2007
- Start Page
- 730
- ISBN/ISSN
- 1520-6025; 0163-3864
- PMID
- 17432902
- DOI
- 10.1021/np060389p