TiO2-nanowired cerebrolysin attenuated hyperthermia induced ubiquitin overexpression and brain pathology
by Sharma, Hari S.; Muresanu, Dafin F.; Lafuente, Jose Vicente; Patnaik, Ranjana; Tian, Z. Ryan; Moessler, Herbert; Sharma, Aruna
Our military personnel are often engaged in combat operations in desert environments during summer months across the World. In such situations, apart from their exposure to missiles, roadside bomb or other explosive related nanoparticles exposure, they are also exposed to silica dust (SiO2) nanoparticles. Previous expts. from our lab. showed that SiO2 exposure exacerbates heat stress induced brain pathol. Thus, this is likely that our soldiers that are exposed to SiO2 nanoparticles under heats tress are prone to central nervous system (CNS) dysfunction. Since ubiquitin is present in almost all cells and responsible for intracellular protein degrdn., in present innovation we examd. ubiquitin expression in heat stress and its modification with SiO2 nanoparticles in a rat model. Our observations show that SiO2 enhances ubiquitin overexpression in heat stress and that could be one of the key mechanisms responsible for brain pathol.
- Conference
- Nanotechnology 2014: Graphene, CNTs, Particles, Films and Composites, Technical Proceedings of the NSTI Nanotechnology Conference and Expo
- Year
- 2014
- Division
- 303-306
- ISBN/ISSN
- 9781482258233