A Study of the Approaches for Preparing Functionalized Transition Metal Complexed 5-Member Ring Quinone Methide Analogs

by Beuterbaugh, Aaron M.; Allison, Neil T.

The quinone methide moiety (1) is present in intermediates that are synthetically and biol. important. They are key moieties in selected antitumor and antibiotics drugs during their metab. process. This project is focused on the study of the prepn. of transition metal five-membered ring analogs of quinone methides as represented by the general structure 2. Here we will report on a study to prep. complexes 4 with varying alkyl substituents from compds. 3, as well as other synthons.