Intercepting the Breslow Intermediate via Claisen Rearrangement: Synthesis of Complex Tertiary Alcohols without Organometallic Reagents
by Al-warsh, Sefat Abdullah; Ayinuola, Kolawole Folayele; Dormi, Silvana Susana; McIntosh, Matt C.
A novel Claisen rearrangement in which the Breslow intermediate is engaged as a hydroxy-substituted N,S-ketene acetal to provide complex 3Â° alcs. without the use of organometallic reagents is reported. The reaction constitutes an unprecedented reactivity mode for the Breslow intermediate.
- Organic Letters
- Start Page
- 1523-7052; 1523-7060