Methods towards thiazolium salt rearrangements.

by Foos, Rebecca H.; Dormi, Silvana; McIntosh, Matt

Much of research within org. chem. surrounds the methods of pharmaceutical development. The compd. thiazole is considered to be a favored structure in many drugs, and as such methods by which it may be used synthetically are of great interest. This study develops the chem. rearrangement of an n-allyl substituted thiazole to a terminal alkylene chain at the beta carbon. Although the study is ongoing, successful rearrangement has been obsd. with yields up to 60%.