Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine
by Beng, Timothy Kum; Yousaf, Taher I.; Coldham, Iain; Gawley, Robert E.
The barriers to enantiomerization of N-trimethylallyl-2-lithiopyrrolidine have been measured in the presence of sparteine, 1, N,N'-diisopropylbispidine, 2, and diaminoalkoxide 3. We have additionally demonstrated a rare example of a catalytic dynamic resolution using either of two ligands, achieving enantiomer ratios of up to 93:7.
- Journal of the American Chemical Society
- Start Page
- 1520-5126; 0002-7863