Ruthenium complex mediated C-18F bond formation for Positron Emission Tomography (PET) tracer synthesis

by Beyzavi, Hassan; Mandal, Debashis; Strebl, Martin; Neumann, Constanze; D'Amato, Erica; Chen, Junting; Hooker, Jacob M.; Ritter, Tobias

The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomog. (PET) tracer development. I will present the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atm., large substrate scope, and translatability to generate doses appropriate for PET imaging.