Metal-Organic Frameworks and Covalent Organic Frameworks as Platforms for Photodynamic Therapy

by Sakamaki, Yoshie; Ozdemir, John; Heidrick, Zachary; Watson, Olivia; Shahsavari, Hamid R.; Fereidoonnezhad, Masood; Khosropour, Ahmad R.; Beyzavi, M. Hassan

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We describe the newest approach to photodynamic therapy (PDT) using metal-organic frameworks (MOFs) and covalent organic frameworks (COFs). PDT's characteristic method of treating cancer as noninvasive and selective has garnered much attention. PDT has entered the realm of nanotechnology to overcome various challenges that are hindering its effectiveness. Porous materials, which are more functional than small molecules, are being explored as platforms for PDT. MOFs are at the forefront of these investigations, and the anti-tumor ability of well-designed nano-MOFs (nMOFs) has recently been reported. We also discuss the possibility of using COFs for future-use PDT.

Journal
Comments on Inorganic Chemistry
Volume
38
Issue
6
Year
2018
Start Page
238
ISBN/ISSN
0260-3594
DOI
10.1080/02603594.2018.1542597