Engineered FGF1 and FGF2 compositions and methods of use thereof

by Thallapuranam, Suresh Kumar; Agrawal, Shilpi; Gundampati, Ravi Kumar; Jayanthi, Srinivas; Wang, Tengjiao; Jones, Jake; Kolenc, Olivia; Lam, Ngoc Thien; Niyonshuti, Isabelle; Balachandran, Kartik; Quinn, Kyle; Chen, Jingyi

Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.

Patent Number
USUS2019284252 A1 2019-09-19
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