Microgel matrix effect (MME): Influence of crosslinking on catalytic behavior

by Sharma, Babloo; Striegler, Susanne

Microgels support and enhance the performance of immobilized catalysts through their allosteric and induced fit effects, and thus provide a new valuable platform for advanced materials. To obtain efficient biomimetic glycosyl transfer catalysts, a polymerization protocol was developed that is applicable to the synthesis of crosslinked microgels via UV-initiated free radical polymerization of miniemulsions at ambient temperature and below. The synthesized microgels were characterized in the solid state and in solution before establishing their catalytic activity toward the hydrolysis of glycosidic bonds. Matrix effects were elaborated as a driving force of the observed catalytic proficiency of the microgels and will be discussed in detail.