Microwave assisted solvent free amination of halo-(pyridine or pyrimidine) without transition metal catalyst
by Narayan, Sanjay; Seelhammer, Troy; Gawley, Robert E.
A solvent free direct amination of halo-(pyridine or pyrimidine) has been developed in good to high yields under computer-con trolled microwave irradiation without transition metal catalyst. This reaction is a solvent and metal free, useful method for coupling of halo-(pyridine or pyrimidine) with pyrrolidine and piperidine derivatives by nucleophilic aromatic substitution (SNAr). (C) 2003 Elsevier Ltd. All rights reserved.
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