Microwave assisted solvent free amination of halo-(pyridine or pyrimidine) without transition metal catalyst

by Narayan, Sanjay; Seelhammer, Troy; Gawley, Robert E.

A solvent free direct amination of halo-(pyridine or pyrimidine) has been developed in good to high yields under computer-con trolled microwave irradiation without transition metal catalyst. This reaction is a solvent and metal free, useful method for coupling of halo-(pyridine or pyrimidine) with pyrrolidine and piperidine derivatives by nucleophilic aromatic substitution (SNAr). (C) 2003 Elsevier Ltd. All rights reserved.

Journal
Tetrahedron Letters
Volume
45
Issue
4
Year
2004
Start Page
757
ISBN/ISSN
1873-3581; 0040-4039
DOI
10.1016/j.tetlet.2003.11.030