Microwave assisted solvent free amination of halo-(pyridine or pyrimidine) without transition metal catalyst
by Narayan, Sanjay; Seelhammer, Troy; Gawley, Robert E.
A solvent free direct amination of halo-(pyridine or pyrimidine) has been developed in good to high yields under computer-con trolled microwave irradiation without transition metal catalyst. This reaction is a solvent and metal free, useful method for coupling of halo-(pyridine or pyrimidine) with pyrrolidine and piperidine derivatives by nucleophilic aromatic substitution (SNAr). (C) 2003 Elsevier Ltd. All rights reserved.
- Journal
- Tetrahedron Letters
- Volume
- 45
- Issue
- 4
- Year
- 2004
- Start Page
- 757
- ISBN/ISSN
- 1873-3581; 0040-4039
- DOI
- 10.1016/j.tetlet.2003.11.030