Evidence of Xenon Transport through the Gramicidin Channel - a Xe-129-Nmr Study

by McKim, Steve; Hinton, James F.

Evidence is presented for Xe transport through the gramicidin A channel. This evidence for Xe transport through gramicidin A channels has been obtained using Xe-129-NMR spectroscopy. Three experiments were utilized. The first experiment involved monitoring the change in the chemical shift of Xe-129 in the presence of increasing gramicidin A concentration, the second observed the effect on the Xe-129 chemical shift with gramicidin A channels photochemically altered by UV light and the third determined the effect of gramicidin A channels blocked by Ba2+ on the Xe-129 chemical shift. The results of these three experiments indicate that Xe transports through the gramicidin A channel.

Journal
Biochimica et Biophysica Acta-Biomembranes
Volume
1193
Issue
1
Year
1994
Start Page
186
ISBN/ISSN
0005-2736
DOI
10.1016/0005-2736(94)90348-4