Nano-2-(dimethylamino)-N-(silica-n-propyl)-N,N-dimethylethanaminium chloride as a novel basic catalyst for the efficient synthesis of pyrido[2,3-d:6,5-d]dipyrimidines

by Zare, Abdolkarim; Kohzadian, Alireza; Abshirini, Zahra; Sajadikhah, Seyed Sajad; Phipps, Joshua; Benamara, Mourad; Beyzavi, M. Hassan

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This study describes the synthesis and characterization of nano-2-(dimethylamino)-N-(silica-n-propyl)-N,N-dimethylethanaminium chloride {nano-[DMSPDE][Cl]}, and its application as a highly effective, heterogeneous and recyclable basic catalyst for the promotion of a useful organic reaction. The catalyst was characterized using FT-IR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) and energy-dispersive X-ray spectroscopy (EDS) methods. The nanocatalyst was successfully used to facilitate the solvent-free preparation of pyrido[2,3-d:6,5-d]dipyrimidines by the multi-component reaction of 2-thiobarbituric acid, arylaldehydes and ammonium acetate. Nano-[DMSPDE][Cl] furnished the products in high yields and in short reaction times, and showed no significant loss of activity after multiple runs. It is noteworthy that, in the literature, pyrido[2,3-d:6,5-d]dipyrimidines have been synthesized using Lewis or acidic catalysts; however, in this work, a basic catalyst has been applied for their preparation.

Journal
New Journal of Chemistry
Volume
43
Issue
5
Year
2019
Start Page
2247
ISBN/ISSN
1144-0546
DOI
10.1039/c8nj04921a