Redox Cycling Behavior of Individual and Binary Mixtures of Catecholamines at Gold Microband Electrode Arrays

by Hu, Mengjia; Fritsch, Ingrid

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The electrochemical redox cycling (RC) behavior of individual and binary mixtures of three catecholamines are investigated using gold microelectrode arrays in vitro. Catecholamines showed reversible or irreversible responses during RC depending on their oxidation products cyclization rate. The RC behavior of the binary mixtures supports the disproportionation reaction of catecholamines, which has been previously reported, but not under RC conditions or with mixtures. This fundamental study provides insights on the effects of complicated mechanisms and kinetics on RC and sets the foundation for future applications of RC for in vivo multi-neurotransmitter analysis.

Journal
Analytical Chemistry
Volume
87
Issue
4
Year
2015
Start Page
2029
ISBN/ISSN
0003-2700
DOI
10.1021/ac5042022