Bioceramic nanowire's intercalation, charge-transfer, pH-buffering, and biocompatibility

by Chen, Feng; Fologea, Daniel; Chakhalian, Jacques; Ali, Syed; Zhou, Huajun; Li, Jing; Lu, Yijiang; Tian, Z. Ryan

ON the basis of our previous publication, we hereby further report a new study on lattice intercalation, charge-transfer, pH buffering, and biocompatibility of cation exchanged titanate nanowires (NWs). Electron- and X-ray diffractions suggested a layered lattice-structure for the NWs, and thermogravimetric anal. revealed how much dehydrated water in the lattice and on the surface of the NWs. On the NWs, the point-of-zero-charge was measured via a pH titrn., while the biocompatibility was evaluated by neuron regeneration. The cytochrome c (a heme protein) on the NW-modified ITO electrode shows a formal potential for electrochem. detecting the cyt.c at pmole-level. The NW-modified glassy carbon electrode was applied for electrochem. sensing a neurotransmitter at µM-level. All these properties have implied to us that the versatile NWs are thermally and chem. stable, biocompatible, cation-exchangeable, high surface-area, useful in tissue engineering and biosensing, etc.