Nanowired delivery of mesenchymal stem cell reduces diabetes induced aggravation brain damage following heatstroke
by Sharma, Hari S.; Feng, Lianyuan; Lafuente, Jose Vicente; Murasanu, Dafin F.; Tian, Z. Ryan; Patnaik, Ranjana; Sharma, Aruna
Our military personnel are often exposed to combat operations in hot environments in summer months (40 to 42°C) that often lead to heatstroke. Since endocrine disorders e.g., diabetes could result from posttraumatic stress disorders (PTSD) in military populations; these soldiers are highly vulnerable to addnl. heat stress. Previous reports from our lab suggest that diabetic rats showed greater brain pathol. after heat stress. This suggests that military personnel with diabetes in heat stress have higher brain pathol. during combat stress or other activities. Since stem cells are known to induce neuroprotection we examd. whether nanodelivery of mesenchymal stem cells (MSCs) could enhance the potential neuroprotective effects of stem cells and reduce the aggravation of brain pathol. in heat stress in diabetic rat model. Our observations clearly show that nanodelivery of MSCs markedly attenuated heat stress induced brain pathol. in diabetic rats.
- Conference
- Nanotechnology 2014: Graphene, CNTs, Particles, Films and Composites, Technical Proceedings of the NSTI Nanotechnology Conference and Expo
- Year
- 2014
- Division
- 246-249
- ISBN/ISSN
- 9781482258233