A Bioconjugated Chlorin-Based Metal-Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers

by Sakamaki, Yoshie; Ozdemir, John; Heidrick, Zachary; Azzun, Anthony; Watson, Olivia; Tsuji, Miu; Salmon, Christopher; Sinha, Arvind; Batta-Mpouma, Joseph; McConnell, Zachary; Fugitt, David; Du, Yuchun; Kim, Jin-Woo; Beyzavi, Hudson

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The field of photodynamic therapy (PDT) has continued to show promise as a potential method for treating tumors. In this work, a photosensitizer (PS) has been delivered to cancer cell lines for PDT by incorporation into the metal-organic framework (MOF) as an organic linker. By functionalizing the surface of MOF nanoparticles with maltotriose, the PS can efficiently target cancer cells with preferential uptake into pancreatic and breast cancer cell lines. Effective targeting overcomes some current problems with PDT including long-term photosensitivity and tumor specificity. Developing a PS with optimal absorption and stability is one of the foremost challenges in PDT, and the synthesis of a chlorin, which is activated by long wavelength light and is resistant to photobleaching, is described. This chlorin-based MOF shows anticancer ability several times higher than that of porphyrin-based MOFs with little toxicity to normal cell lines and no dark toxicity.

Journal
ACS Applied Bio Materials
Volume
4
Issue
2
Year
2021
Start Page
1432
ISBN/ISSN
0079-6123
DOI
10.1021/acsabm.0c01324